gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0184 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADENOSINE RECEPTOR
SUBFAMILY A2A

Cross References:
UniProt Q60613 EMBL Y13344 | Y13345 | Y13346 | U05672
InterPro IPR001513 | IPR001634 | IPR000276 GPCRDB AA2AR_MOUSE
PRINTS PR00553 | PR00424 | PR00237 PFAM PF00001

Details:
NAME ADENOSINE RECEPTOR_A2A_Mus musculus
DESCRIPTION Adenosine receptor A2a.
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Adora2a
SEQUENCE
MGSSVYIMVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFA
ITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGMKAKG
IIAICWVLSFAIGLTPMLGWNNCSQTDENSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAF
VLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALC
WLPLHIINCFTFFCSTCQHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRT
HVLRRQEPFRAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSAPHSGRRPNGYTLGP
GGGGSTQGSPGDVELLTQEHQEGQEHPGLGDHLAQGRVGTASWSSEFAPS
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12804599
HETERODIMER INFORMATION Forms heterodimers with Dopamine D2. Heterodimerization results in co-desensitization and co-internalization of the receptors METHOD Immunoprecipitation REFERENCES 11872740
HETERODIMER INFORMATION Forms heterodimers with Metabotropic Glutamate Receptors 5. Dimerization results in enhanced ERK activity METHOD Immunoprecipitation REFERENCES 12189203

Coupling with G-proteins:
Family:Gs REFERENCES:1662665
1GPR0123Galpha-s-Mus musculus-2
2GPR0391Galpha-s-Mus musculus


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory