gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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Entry 1 of 1 :: GPCR1911 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY OPIOID AND OPIOID-LIKE RECEPTOR
SUBFAMILY MU OPIOID PEPTIDE (MOR)

Cross References:
UniProt P97266 EMBL U67928
InterPro IPR000276 | IPR000105 | IPR001418 GPCRDB OPRM_CAVPO
PRINTS PR00237 | PR00384 PFAM PF00001

Details:
NAME OPIOID AND OPIOID-LIKE RECEPTOR_MU OPIOID PEPTIDE (MOR)_Cavia porcellus
DESCRIPTION Mu-type opioid receptor .
SPECIES Cavia porcellus COMMON NAME Guinea pig NCBI Taxonomy 10141
GENE OPRM1
SEQUENCE
YTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSI
FTLCTMSVDRYIAVCHPVKALDFRTPRNAKTVNVCNWI
FRAGMENT YES

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12217652
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10842167
HETERODIMER INFORMATION Forms heterodimers with delta Opioid Peptide Receptor. Dimerization results in Changing the binding properties of opiate ligands and altered G-protein coupling METHOD Immunoprecipitation REFERENCES 10842167 | 11069979
HETERODIMER INFORMATION Forms heterodimers with SST2 RECEPTORS. Dimerization results in cross-modulation of receptor phosphorylation, internalization and desensitization METHOD Immunoprecipitation REFERENCES 11896051

Coupling with G-proteins:
Family:Gi/o REFERENCES:8393525
1GPR0107Galpha-i3-Cavia porcellus
2GPR0216Galpha-i1-Cavia porcellus
3GPR0224Galpha-i2-Cavia porcellus


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