| Details: |
| NAME |
ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1A(Adrenoceptor)_Rattus norvegicus |
| DESCRIPTION |
Alpha-1A adrenergic receptor (Alpha 1A-adrenoceptor) (Alpha 1A-adrenoreceptor) (Alpha-1C adrenergic receptor). |
| SPECIES |
Rattus norvegicus |
COMMON NAME |
Rat |
NCBI Taxonomy |
10116 |
| GENE |
Adra1a | Adra1c |
| SEQUENCE |
MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSV
THYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCII
SIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINE
EPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKN
VPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPD
FKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTL
HPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACT
TARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
|
FRAGMENT |
NO
|
|
|
|
|
Homepage
|
| Dimerization: |
| HOMODIMER INFORMATION |
There is experimental evidence for homo-dimerization
|
METHOD |
Immunoprecipitation, Fluorescence Resonance Energy Transfer (FRET)
|
REFERENCES |
12888550
|
| HETERODIMER INFORMATION |
Forms heterodimers with A1B Adrenoceptors. Heterodimerization results in altered internalization of the receptor
|
METHOD |
Fluorescence Resonance Energy Transfer (FRET)
|
REFERENCES |
12888550
|
| Scaffold: |
| TYPE |
nNOS( neuronal nitric oxide synthase) NOS1
|
REFERENCES |
12184796
|
| Coupling with G-proteins: |
| Family:G12/13 |
REFERENCES: | 12433842 | | 1 | GPR0036 | Galpha-12-Rattus norvegicus | | Family:Gq/11 |
REFERENCES: | 8396931 | | 2 | GPR0032 | Galpha-11-Rattus norvegicus | | 3 | GPR0242 | Galpha-q-Rattus norvegicus |
|
biol.uoa.gr
for comments, corrections and
data (sequence) submission.
