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gpDB::GPCR View
Entry 1 of 1 :: GPCR0218 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADRENOCEPTOR (A1-ADRENOCEPTOR)
SUBFAMILY A1B(Adrenoceptor)

Cross References:
UniProt P11615 EMBL X14050
InterPro IPR001115 | IPR002233 | IPR000276 GPCRDB ADA1B_CANFA
PRINTS PR01103 | PR00556 | PR00237 PFAM PF00001

Details:
NAME ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1B(Adrenoceptor)_Canis familiaris
DESCRIPTION Alpha-1B adrenergic receptor .
SPECIES Canis familiaris COMMON NAME Dog NCBI Taxonomy 9615
GENE ADRA1B | RDC5
SEQUENCE
VLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLV
TRRKAILALLGVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLA
VILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRS
SIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLG
YFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRRRRRRRRRLGGCAYTYRPWTRGGSLER
SQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRAAPPPVELCAVPEWKAPGALLSLPAP
QPPGRRGRRDSGPLFTFRLLAERGSPAAGDGACRPAPDAANGQPGFKTNMPLAPGQF
FRAGMENT YES

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation, Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12888550
HETERODIMER INFORMATION Forms heterodimers with A1A Adrenoceptors. Heterodimerization results in altered internalization of the receptor METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12888550

Scaffold:
TYPE nNOS( neuronal nitric oxide synthase) NOS1 REFERENCES 12184796

Coupling with G-proteins:
Family:Gq/11 REFERENCES:1662393
1GPR0233Galpha-q-Canis familiaris


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory