gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0232 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADRENOCEPTOR (A2-ADRENOCEPTOR)
SUBFAMILY A2A(Adrenoceptor)

Cross References:
UniProt P08913 | Q2I8G2 | Q2XN99 | Q86TH8 | Q9BZK1 EMBL M18415 | M23533 | AF281308 | AF316894 | DQ149926 | AF284095 | AF262016 | AY032736 | DQ285607 | AL158163 | BC035047 | BC050414
InterPro IPR001946 | IPR015695 | IPR002233 | IPR000276 PDB 1HLL | 1HO9 | 1HOD | 1HOF GPCRDB ADA2A_HUMAN
GENEID 150 MIM 104210
PRINTS PR01103 | PR00558 | PR00237 PFAM PF00001

Details:
NAME ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2A(Adrenoceptor)_Homo sapiens
DESCRIPTION Alpha-2A adrenergic receptor (Alpha-2A adrenoceptor) (Alpha-2Aadrenoreceptor) (Alpha-2AAR) (Alpha-2 adrenergic receptor subtypeC10).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE ADRA2A | ADRA2R | ADRAR
SEQUENCE
MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFT
SRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSS
IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGG
PQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVA
APPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSD
HAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKAS
RWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSS
LNPVIYTIFNHDFRRAFKKILCRGDRKRIV
FRAGMENT NO

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Dimerization:
HETERODIMER INFORMATION Forms heterodimers with B1 Adrenoceptors. Heterodimerization results in altered ligand binding and internalization of the receptor METHOD Immunoprecipitation REFERENCES 12529373

Scaffold:
TYPE 14-3-3 ksi REFERENCES 10224112
TYPE Spinophilin/neurabin II REFERENCES 11154706

Coupling with G-proteins:
Family:Gi/o REFERENCES:8662784
1GPR0020Galpha-o1-Homo sapiens
2GPR0109Galpha-i3-Homo sapiens
3GPR0218Galpha-i1-Homo sapiens-1
4GPR0226Galpha-i2-Homo sapiens-2
5GPR0261Galpha-i1-Homo sapiens-2
6GPR0334Galpha-o-Homo sapiens
7GPR0365Galpha-i2-Homo sapiens-1
Family:Gq/11 REFERENCES:8662784
8GPR0002Galpha-q-Homo sapiens-2
9GPR0029Galpha-11-Homo sapiens
10GPR0237Galpha-q-Homo sapiens-1
Family:Gs REFERENCES:8662784
11GPR0119Galpha-s-Homo sapiens-2
12GPR0263Galpha-s-Homo sapiens-4
13GPR0266Galpha-s-Homo sapiens-5
14GPR0267Galpha-s-Homo sapiens-6
15GPR0277Galpha-s-Homo sapiens-7
16GPR0278Galpha-s-Homo sapiens
17GPR0395Galpha-s-Homo sapiens-3


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory