gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2372 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY P2Y RECEPTOR
SUBFAMILY P2Y1

Cross References:
UniProt P49651 EMBL U22830
InterPro IPR001277 | IPR000276 | IPR002286 | IPR000142 GPCRDB P2RY1_RAT
GENEID 25265
PRINTS PR00645 | PR00237 | PR00595 | PR01157 PFAM PF00001

Details:
NAME P2Y RECEPTOR_P2Y1_Rattus norvegicus
DESCRIPTION P2Y purinoceptor 1 (ATP receptor) (P2Y1) (Purinergic receptor).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE P2ry1
SEQUENCE
MTEVPWSAVPNGTDAAFLAGLGSLWGNSTIASTAAVSSSFRCALIKTGFQFYYLPAVYIL
VFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFG
DVMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAIYVSVLVWLIVV
VAISPILFYSGTGIRKNKTVTCYDSTSDEYLRSYFIYSMCTTVAMFCIPLVLILGCYGLI
VRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPEMCDFND
RVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEEMTLN
ILSEFKQNGDTSL
FRAGMENT NO

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Dimerization:
HETERODIMER INFORMATION Forms heterodimers with Adenosine A1 Receptor. Heterodimerization results in altered ligand binding METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11390975 | 12417330 | 12123822

Scaffold:
TYPE NHERF1( Na+/H+ exchange regulatory factor) /EBP50( ezrin-radixin-moesin binding phosphoprotein 50-kD protein) REFERENCES 9671706

Coupling with G-proteins:
Family:Gq/11 REFERENCES:8159738
1GPR0032Galpha-11-Rattus norvegicus
2GPR0242Galpha-q-Rattus norvegicus


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