gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2454 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY PROTEASE-ACTIVATED RECEPTOR
SUBFAMILY PAR1

Cross References:
UniProt P25116 | Q96RF7 | Q9BUN4 EMBL M62424 | AF391809 | BC002464 | BC051909
InterPro IPR000276 | IPR003912 | IPR000935 PDB 1NRN | 1NRO | 1NRP | 1NRQ | 1NRR GPCRDB PAR1_HUMAN
GENEID 2149 MIM 187930
PRINTS PR00237 | PR01428 | PR00908 PFAM PF00001

Details:
NAME PROTEASE-ACTIVATED RECEPTOR_PAR1_Homo sapiens
DESCRIPTION Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor)(Coagulation factor II receptor).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE F2R | CF2R | PAR1 | TR
SEQUENCE 
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEE
KNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLN
IMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTA
AFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLK
EQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSS
AVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVS
SISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIY
KKLLT
 FRAGMENT NO

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Scaffold:
TYPE SNX1( sorting nexin) REFERENCES 12058063

Coupling with G-proteins:
Family:G12/13 REFERENCES:12954641
1GPR0034Galpha-12-Homo sapiens
2GPR0037Galpha-13-Homo sapiens
Family:Gi/o REFERENCES:10644723
3GPR0020Galpha-o1-Homo sapiens
4GPR0109Galpha-i3-Homo sapiens
5GPR0218Galpha-i1-Homo sapiens-1
6GPR0226Galpha-i2-Homo sapiens-2
7GPR0261Galpha-i1-Homo sapiens-2
8GPR0334Galpha-o-Homo sapiens
9GPR0365Galpha-i2-Homo sapiens-1
Family:Gq/11 REFERENCES:10644723
10GPR0002Galpha-q-Homo sapiens-2
11GPR0029Galpha-11-Homo sapiens
12GPR0237Galpha-q-Homo sapiens-1

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athina University of Athens
 Faculty of Biology
 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory