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gpDB::G-protein View
Entry 1 of 1 :: GPR0034 ::
CLASS Galpha
FAMILY G12/13
SUBFAMILY Galpha-12
TYPE Galpha-12

Cross References:
UniProt Q03113 | Q2T9L1 | Q86UM8 | Q8TD71 | Q9UDU9 EMBL L01694 | AF493901 | AC006028 | AC004933 | BC111464
InterPro IPR001019 | IPR000469 | IPR011025
PRODOM PD000281
GENEID 2768 MIM 604394
PRINTS PR00318 | PR00440 PFAM PF00503

Details:
NAME Galpha-12-Homo sapiens
DESCRIPTION Guanine nucleotide-binding protein alpha-12 subunit (G alpha-12).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
POST TRANSLATION MODIFICATIONS null GENE GNA12
SEQUENCE 
MSGVVRTLSRCLLPAEAGGARERRAGSGARDAEREARRRSRDIDALLARERRAVRRLVKI
LLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQ
YSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGESVK
YFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQ
CFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDL
LVEKVKTVSIKKHFPDFRGDPHRLEDVQRYLVQCFDRKRRNRSKPLFHHFTTAIDTENVR
FVFHAVKDTILQENLKDIMLQ
 FRAGMENT NO
FUNCTION Guanine nucleotide-binding proteins (G proteins) ares involved as modulators or transducers in various transmembranes signaling systems
Effectors:
1EFF0324E cadherin-Homo sapiens-1Stimulation (stimulation of h-catenin release)15251227 | 14607242 | 11136230
2EFF0325E cadherin-Homo sapiens-2Stimulation (stimulation of h-catenin release)15251227 | 14607242 | 11136230
3EFF0326E cadherin-Homo sapiens-3Stimulation (stimulation of h-catenin release)15251227 | 14607242 | 11136230
4EFF0434LARG RhoGEF-Homo sapiens-1Stimulation (indirect activation of Rho and stress fiber formation)15251227 | 12024019 | 14607242
5EFF0435LARG RhoGEF-Homo sapiens-2Stimulation (indirect activation of Rho and stress fiber formation)15251227 | 12024019 | 14607242
6EFF0443p115 RhoGEF-Homo sapiensStimulation (indirect activation of Rho and stress fiber formation)15251227 | 14607242
7EFF0444PDZ RhoGEF-Homo sapiens-1Stimulation (indirect activation of Rho and stress fiber formation)15251227 | 11799111 | 14607242
8EFF0445PDZ RhoGEF-Homo sapiens-2Stimulation (indirect activation of Rho and stress fiber formation)15251227 | 11799111 | 14607242
9EFF0693Ras GTPase activating protein-2-Homo sapiensStimulation (indirect activation of ras)15251227

Coupling with GPCRs:
1GPCR00845-HYDROXYTRYPTAMINE RECEPTOR_5-HT-2C_Homo sapiens14722258 | 11572865
2GPCR00895-HYDROXYTRYPTAMINE RECEPTOR_5-HT-4_Homo sapiens11923294
3GPCR0200ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1A(Adrenoceptor)_Homo sapiens-612433842
4GPCR0213ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1A(Adrenoceptor)_Homo sapiens-312433842
5GPCR0215ADRENOCEPTOR (A1-ADRENOCEPTOR)_A1A(Adrenoceptor)_Homo sapiens-412433842
6GPCR0414ANGIOTENSIN RECEPTOR_AT1_Homo sapiens-19092554 | 9287322
7GPCR0429ANGIOTENSIN RECEPTOR_AT1_Homo sapiens-29092554 | 9287322
8GPCR0467BRADYKININ RECEPTOR_B2_Homo sapiens7946358
9GPCR0450BOMBESIN RECEPTOR_BB2_Homo sapiens11507098
10GPCR0705CHEMOTACTIC PEPTIDE RECEPTOR_C3A_Homo sapiens12165538
11GPCR2640EXTRACELLULAR CALCIUM-SENSING RECEPTOR_CASR_Homo sapiens12954603
12GPCR0737CHOLECYSTOKININ AND GASTRIN RECEPTOR_CCK1_Homo sapiens12853286
13GPCR0807DOPAMINE RECEPTOR_D5_Homo sapiens12623966
14GPCR0814ENDOTHELIN RECEPTOR_ET-A_Homo sapiens10364236
15GPCR0818ENDOTHELIN RECEPTOR_ET-B_Homo sapiens10199825
16GPCR0835GALANIN RECEPTOR_GAL2_Homo sapiens10980593
17GPCR1007LYSOPHOSPHOLIPID RECEPTOR_LPA1_Homo sapiens9600933
18GPCR1013LYSOPHOSPHOLIPID RECEPTOR_LPA2_Homo sapiens12215548
19GPCR1015LYSOPHOSPHOLIPID RECEPTOR_LPA3_Homo sapiens-112069829
20GPCR1018LYSOPHOSPHOLIPID RECEPTOR_LPA3_Homo sapiens-212069829
21GPCR0116ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M1_Homo sapiens-110821841
22GPCR0120ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M1_Homo sapiens-210821841
23GPCR0139ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M3_Homo sapiens-211036069
24GPCR0142ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M3_Homo sapiens-111036069
25GPCR2502TACHYKININ RECEPTOR_NK1_Homo sapiens8999927
26GPCR2454PROTEASE-ACTIVATED RECEPTOR_PAR1_Homo sapiens12954641
27GPCR1090LYSOPHOSPHOLIPID RECEPTOR_S1P2_Homo sapiens10488065
28GPCR1097LYSOPHOSPHOLIPID RECEPTOR_S1P3_Homo sapiens10488065
29GPCR1100LYSOPHOSPHOLIPID RECEPTOR_S1P5_Homo sapiens10799507
30GPCR2801SMOOTHENED_smoothened_Homo sapiens14723707
31GPCR2449PROSTANOID RECEPTOR_TP_Homo sapiens10318854
32GPCR0886GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Homo sapiens-28552586
33GPCR0887GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Homo sapiens-18552586
34GPCR0889GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Homo sapiens-38552586
35GPCR2559VASOPRESSIN AND OXYTOCIN RECEPTOR_V1A_Homo sapiens10364236



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