gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2457 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY PROTEASE-ACTIVATED RECEPTOR
SUBFAMILY PAR1

Cross References:
UniProt P47749 EMBL U09632
InterPro IPR000276 | IPR003912 | IPR000935 GPCRDB PAR1_XENLA
GENEID 378526
PRINTS PR00237 | PR01428 | PR00908 PFAM PF00001

Details:
NAME PROTEASE-ACTIVATED RECEPTOR_PAR1_Xenopus laevis
DESCRIPTION Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor).
SPECIES Xenopus laevis COMMON NAME African clawed frog NCBI Taxonomy 8355
GENE f2r
SEQUENCE 
MMELRVLLLLLLLTLLGAMGSLCLANSDTQAKGAHSNNMTIKTFRIFDDSESEFEEIPWD
ELDESGEGSGDQAPVSRSARKPIRRNITKEAEQYLSSQWLTKFVPSLYTVVFIVGLPLNL
LAIIIFLFKMKVRKPAVVYMLNLAIADVFFVSVLPFKIAYHLSGNDWLFGPGMCRIVTAI
FYCNMYCSVLLIASISVDRFLAVVYPMHSLSWRTMSRAYMACSFIWLISIASTIPLLVTE
QTQKIPRLDITTCHDVLDLKDLKDFYIYYFSSFCLLFFFVPFIITTICYIGIIRSLSSSS
IENSCKKTRALFLAVVVLCVFIICFGPTNVLFLTHYLQEANEFLYFAYILSACVGSVSCC
LDPLIYYYASSQCQRYLYSLLCCRKVSEPGSSTGQLMSTAMKNDNCSTNAKSSIYKKLLA
 FRAGMENT NO

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Scaffold:
TYPE SNX1( sorting nexin) REFERENCES 12058063

Coupling with G-proteins:
Family:Gi/o REFERENCES:10644723
1GPR0016Galpha-o-Xenopus laevis
2GPR0112Galpha-i3-Xenopus laevis
3GPR0222Galpha-i1-Xenopus laevis
4GPR0271Galpha-o1-Xenopus laevis
5GPR0272Galpha-i-Xenopus laevis
Family:Gq/11 REFERENCES:10644723
6GPR0033Galpha-11-Xenopus laevis-2
7GPR0243Galpha-q-Xenopus laevis
8GPR0314Galpha-11-Xenopus laevis-1

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athina University of Athens
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 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory