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gpDB::G-protein View
Entry 1 of 1 :: GPR0222 ::
CLASS Galpha
FAMILY Gi/o
SUBFAMILY Galpha-i
TYPE Galpha-i1

Cross References:
UniProt P27044 | Q6GPC5 EMBL X56089 | BC042243 | BC073216
InterPro IPR001019 | IPR001408 | IPR011025
PRODOM PD000281
GENEID 380034 | 399463
PRINTS PR00318 | PR00441 PFAM PF00503

Details:
NAME Galpha-i1-Xenopus laevis
DESCRIPTION Guanine nucleotide-binding protein G(i), alpha-1 subunit (Adenylatecyclase-inhibiting G alpha protein).
SPECIES Xenopus laevis COMMON NAME African clawed frog NCBI Taxonomy 8355
POST TRANSLATION MODIFICATIONS null GENE gnai1
SEQUENCE 
MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAG
YSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDPSRADDARQLFVLAGAAEEGFMT
AELAGVIKRLWKDGGVQACFNRSREYQLNDSAAYYLNDLDRIAQNSYIPTQQDVLRTRVK
TTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM
NRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKRSPLTICYPEYPGSNTYEEAA
AYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
 FRAGMENT NO
FUNCTION Guanine nucleotide-binding proteins (G proteins) ares involved as modulators or transducers in various transmembranes signaling systems
Effectors:
1EFF0043Adenylate cyclase-6-Xenopus laevisInhibition15251227 | 15922020 | 14993377 | 11376933
2EFF0407Kir 3.1(GIRK1)-Xenopus laevis-1Stimulation15251227 | 14963032 | 11779482
3EFF0408Kir 3.1(GIRK1)-Xenopus laevis-2Stimulation15251227 | 14963032 | 11779482
4EFF0672Rac-Xenopus laevisStimulation11099498
5EFF0871Src tyrosine kinase-Xenopus laevisStimulation11007482 | 15251227 | 12209124
6EFF1382Tubulin-Xenopus laevis-1Stimulation of GTPase activity10224115 | 15251227 | 16380086
7EFF1384Tubulin-Xenopus laevis-11Stimulation of GTPase activity10224115 | 15251227 | 16380086
8EFF1385Tubulin-Xenopus laevis-12Stimulation of GTPase activity10224115 | 15251227 | 16380086
9EFF1386Tubulin-Xenopus laevis-13Stimulation of GTPase activity10224115 | 15251227 | 16380086
10EFF1387Tubulin-Xenopus laevis-14Stimulation of GTPase activity10224115 | 15251227 | 16380086
11EFF1388Tubulin-Xenopus laevis-15Stimulation of GTPase activity10224115 | 15251227 | 16380086
12EFF1389Tubulin-Xenopus laevis-16Stimulation of GTPase activity10224115 | 15251227 | 16380086
13EFF1390Tubulin-Xenopus laevis-17Stimulation of GTPase activity10224115 | 15251227 | 16380086
14EFF1391Tubulin-Xenopus laevis-18Stimulation of GTPase activity10224115 | 15251227 | 16380086
15EFF1392Tubulin-Xenopus laevis-19Stimulation of GTPase activity10224115 | 15251227 | 16380086
16EFF1393Tubulin-Xenopus laevis-2Stimulation of GTPase activity10224115 | 15251227 | 16380086
17EFF1394Tubulin-Xenopus laevis-20Stimulation of GTPase activity10224115 | 15251227 | 16380086
18EFF1395Tubulin-Xenopus laevis-21Stimulation of GTPase activity10224115 | 15251227 | 16380086
19EFF1396Tubulin-Xenopus laevis-22Stimulation of GTPase activity10224115 | 15251227 | 16380086
20EFF1397Tubulin-Xenopus laevis-23Stimulation of GTPase activity10224115 | 15251227 | 16380086
21EFF1398Tubulin-Xenopus laevis-24Stimulation of GTPase activity10224115 | 15251227 | 16380086
22EFF1399Tubulin-Xenopus laevis-25Stimulation of GTPase activity10224115 | 15251227 | 16380086
23EFF1400Tubulin-Xenopus laevis-26Stimulation of GTPase activity10224115 | 15251227 | 16380086
24EFF1401Tubulin-Xenopus laevis-27Stimulation of GTPase activity10224115 | 15251227 | 16380086
25EFF1402Tubulin-Xenopus laevis-28Stimulation of GTPase activity10224115 | 15251227 | 16380086
26EFF1403Tubulin-Xenopus laevis-10Stimulation of GTPase activity10224115 | 15251227 | 16380086
27EFF1404Tubulin-Xenopus laevis-3Stimulation of GTPase activity10224115 | 15251227 | 16380086
28EFF1405Tubulin-Xenopus laevis-9Stimulation of GTPase activity10224115 | 15251227 | 16380086
29EFF1406Tubulin-Xenopus laevis-4Stimulation of GTPase activity10224115 | 15251227 | 16380086
30EFF1407Tubulin-Xenopus laevis-5Stimulation of GTPase activity10224115 | 15251227 | 16380086
31EFF1408Tubulin-Xenopus laevis-6Stimulation of GTPase activity10224115 | 15251227 | 16380086
32EFF1409Tubulin-Xenopus laevis-7Stimulation of GTPase activity10224115 | 15251227 | 16380086
33EFF1410Tubulin-Xenopus laevis-8Stimulation of GTPase activity10224115 | 15251227 | 16380086

Coupling with GPCRs:
1GPCR00185-HYDROXYTRYPTAMINE RECEPTOR_5-HT-1A_Xenopus laevis3138543
2GPCR0169ADENOSINE RECEPTOR_A1_Xenopus laevis1662665
3GPCR0410ANGIOTENSIN RECEPTOR_AT1_Xenopus laevis-11310139
4GPCR0415ANGIOTENSIN RECEPTOR_AT1_Xenopus laevis-21310139
5GPCR0606CHEMOKINE RECEPTOR (CC)_CXCR4_Xenopus laevis8629022
6GPCR0774DOPAMINE RECEPTOR_D2_Xenopus laevis-12974511
7GPCR0776DOPAMINE RECEPTOR_D2_Xenopus laevis-22974511
8GPCR2729FRIZZLED_Frizzled-1_Xenopus laevis11563835
9GPCR0857GLYCOPROTEIN HORMONE RECEPTOR_FSH RECEPTOR_Xenopus laevis9139796
10GPCR1017LYSOPHOSPHOLIPID RECEPTOR_LPA3_Xenopus laevis12069829
11GPCR0876GLYCOPROTEIN HORMONE RECEPTOR_LSH RECEPTOR_Xenopus laevis1516719
12GPCR0147ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M4_Xenopus laevis3037705
13GPCR1216MELATONIN RECEPTOR_MT1_Xenopus laevis-27946354
14GPCR1223MELATONIN RECEPTOR_MT1_Xenopus laevis-17946354
15GPCR1227MELATONIN RECEPTOR_MT2_Xenopus laevis12721330
16GPCR2457PROTEASE-ACTIVATED RECEPTOR_PAR1_Xenopus laevis10644723
17GPCR1071LYSOPHOSPHOLIPID RECEPTOR_S1P1_Xenopus laevis-19488656
18GPCR1080LYSOPHOSPHOLIPID RECEPTOR_S1P1_Xenopus laevis-29488656
19GPCR2807SMOOTHENED_smoothened_Xenopus laevis10835429
20GPCR1252NEUROPEPTIDE Y RECEPTOR_Y1_Xenopus laevis1321422



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