gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2477 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY SOMATOSTATIN RECEPTOR
SUBFAMILY SST2

Cross References:
UniProt P34993 EMBL L06613
InterPro IPR000276 | IPR000586 | IPR002074 GPCRDB SSR2_BOVIN
GENEID 282083
PRINTS PR00237 | PR00246 | PR00588 PFAM PF00001

Details:
NAME SOMATOSTATIN RECEPTOR_SST2_Bos taurus
DESCRIPTION Somatostatin receptor type 2 (SS2R) (SRIF-1).
SPECIES Bos taurus COMMON NAME Bovine NCBI Taxonomy 9913
GENE SSTR2
SEQUENCE
MDLVSELNETQPWLTTPFDLNGSVGAANISNQTEPYYDLASNVVLTFIYFVVCIIGLCGN
TLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTV
DGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWGVSLLVILPIMIYA
GLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIR
VGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVVLT
YANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLL
NGDLQTSI
FRAGMENT NO

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Dimerization:
HETERODIMER INFORMATION Forms heterodimer with SST3 Receptor. Dimerization results in inactivation of SST3 Receptor function METHOD Immunoprecipitation REFERENCES 11134004
HETERODIMER INFORMATION Forms heterodimers with MU OPIOID RECEPTORS. Dimerization results in cross-modulation of receptor phosphorylation, internalization and desensitization METHOD Immunoprecipitation REFERENCES 11896051

Scaffold:
TYPE Shank1/SSTRIP( somatostatin receptor interacting protein) /synamon REFERENCES 10551867
TYPE Shank2/ProSAP1( proline-rich synapse-associated protein 1) /CortBP1 REFERENCES 10373412

Coupling with G-proteins:
Family:Gi/o REFERENCES:7622071
1GPR0017Galpha-o1-Bos taurus
2GPR0219Galpha-i1-Bos taurus
3GPR0294Galpha-i2-Bos taurus-2
4GPR0295Galpha-i2-Bos taurus-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory