gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2481 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY SOMATOSTATIN RECEPTOR
SUBFAMILY SST2

Cross References:
UniProt P30680 EMBL M96817 | M93273
InterPro IPR000276 | IPR000586 | IPR002074 GPCRDB SSR2_RAT
GENEID 54305
PRINTS PR00237 | PR00246 | PR00588 PFAM PF00001

Details:
NAME SOMATOSTATIN RECEPTOR_SST2_Rattus norvegicus
DESCRIPTION Somatostatin receptor type 2 (SS2R) (SRIF-1).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Sstr2
SEQUENCE
MELTSEQFNGSQVWIPSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCG
NTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMT
VDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWGVSLLVILPIMIY
AGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGI
RVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVIL
TYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGAEDGERSDSKQDKSRLNETTETQRTL
LNGDLQTSI
FRAGMENT NO

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Dimerization:
HETERODIMER INFORMATION Forms heterodimer with SST3 Receptor. Dimerization results in inactivation of SST3 Receptor function METHOD Immunoprecipitation REFERENCES 11134004
HETERODIMER INFORMATION Forms heterodimers with MU OPIOID RECEPTORS. Dimerization results in cross-modulation of receptor phosphorylation, internalization and desensitization METHOD Immunoprecipitation REFERENCES 11896051

Scaffold:
TYPE Shank1/SSTRIP( somatostatin receptor interacting protein) /synamon REFERENCES 10551867
TYPE Shank2/ProSAP1( proline-rich synapse-associated protein 1) /CortBP1 REFERENCES 10373412

Coupling with G-proteins:
Family:Gi/o REFERENCES:7622071
1GPR0026Galpha-o-Rattus norvegicus
2GPR0111Galpha-i3-Rattus norvegicus
3GPR0221Galpha-i1-Rattus norvegicus
4GPR0229Galpha-i2-Rattus norvegicus


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory