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gpDB::G-protein View
Entry 1 of 1 :: GPR0229 ::
CLASS Galpha
FAMILY Gi/o
SUBFAMILY Galpha-i
TYPE Galpha-i2

Cross References:
UniProt P04897 EMBL M12672 | M17528 | BC078806
InterPro IPR001019 | IPR001408 | IPR011025
PRODOM PD000281
GENEID 81664
PRINTS PR00318 | PR00441 PFAM PF00503

Details:
NAME Galpha-i2-Rattus norvegicus
DESCRIPTION Guanine nucleotide-binding protein G(i), alpha-2 subunit (Adenylatecyclase-inhibiting G alpha protein).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
POST TRANSLATION MODIFICATIONS null GENE Gnai2 | Gnai-2
SEQUENCE 
MGCTVSAEDKAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEDG
YSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPQRADDARQLFALSCAAEEQGML
PEDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRV
KTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEE
MNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKITQSPLTICFPEYTGANKYDEA
ASYIQSKFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
 FRAGMENT NO
FUNCTION Guanine nucleotide-binding proteins (G proteins) ares involved as modulators or transducers in various transmembranes signaling systems
Effectors:
1EFF0036Adenylate cyclase-5-Rattus norvegicusInhibition15251227 | 15922020 | 14993377 | 11376933
2EFF0042Adenylate cyclase-6-Rattus norvegicusInhibition15251227 | 15922020 | 14993377 | 11376933
3EFF0403Kir 3.1(GIRK1)-Rattus norvegicus-1Stimulation15251227 | 14963032 | 11779482
4EFF0404Kir 3.1(GIRK1)-Rattus norvegicus-2Stimulation15251227 | 14963032 | 11779482
5EFF0405Kir 3.1(GIRK1)-Rattus norvegicus-3Stimulation15251227 | 14963032 | 11779482
6EFF0416Kir 3.2(GIRK2)-Rattus norvegicus-1Stimulation15251227 | 14963032 | 11779482
7EFF0417Kir 3.2(GIRK2)-Rattus norvegicus-2Stimulation15251227 | 14963032 | 11779482
8EFF0418Kir 3.2(GIRK2)-Rattus norvegicus-3Stimulation15251227 | 14963032 | 11779482
9EFF0419Kir 3.2(GIRK2)-Rattus norvegicus-4Stimulation15251227 | 14963032 | 11779482
10EFF0423Kir 3.3(GIRK3)-Rattus norvegicusStimulation15251227 | 14963032 | 11779482
11EFF0431Kir 3.4(GIRK4)-Rattus norvegicusStimulation15251227 | 14963032 | 11779482
12EFF0667Rac-Rattus norvegicus-1Stimulation11099498
13EFF0668Rac-Rattus norvegicus-2Stimulation11099498
14EFF0669Rac-Rattus norvegicus-3Stimulation11099498
15EFF0867Src tyrosine kinase-Rattus norvegicus-1Stimulation11007482 | 15251227 | 12209124
16EFF0868Src tyrosine kinase-Rattus norvegicus-2Stimulation11007482 | 15251227 | 12209124
17EFF0870Src tyrosine kinase-Rattus norvegicus-3Stimulation11007482 | 15251227 | 12209124
18EFF1336Tubulin-Rattus norvegicus-10Stimulation of GTPase activity10224115 | 15251227 | 16380086
19EFF1337Tubulin-Rattus norvegicus-11Stimulation of GTPase activity10224115 | 15251227 | 16380086
20EFF1338Tubulin-Rattus norvegicus-12Stimulation of GTPase activity10224115 | 15251227 | 16380086
21EFF1339Tubulin-Rattus norvegicus-2Stimulation of GTPase activity10224115 | 15251227 | 16380086
22EFF1340Tubulin-Rattus norvegicus-1Stimulation of GTPase activity10224115 | 15251227 | 16380086
23EFF1342Tubulin-Rattus norvegicus-3Stimulation of GTPase activity10224115 | 15251227 | 16380086
24EFF1343Tubulin-Rattus norvegicus-4Stimulation of GTPase activity10224115 | 15251227 | 16380086
25EFF1344Tubulin-Rattus norvegicus-5Stimulation of GTPase activity10224115 | 15251227 | 16380086
26EFF1345Tubulin-Rattus norvegicus-6Stimulation of GTPase activity10224115 | 15251227 | 16380086
27EFF1346Tubulin-Rattus norvegicus-7Stimulation of GTPase activity10224115 | 15251227 | 16380086
28EFF1347Tubulin-Rattus norvegicus-8Stimulation of GTPase activity10224115 | 15251227 | 16380086
29EFF1348Tubulin-Rattus norvegicus-9Stimulation of GTPase activity10224115 | 15251227 | 16380086

Coupling with GPCRs:
1GPCR00155-HYDROXYTRYPTAMINE RECEPTOR_5-HT-1A_Rattus norvegicus3138543
2GPCR00275-HYDROXYTRYPTAMINE RECEPTOR_5-HT-1B_Rattus norvegicus1351684
3GPCR00435-HYDROXYTRYPTAMINE RECEPTOR_5-HT-1D_Rattus norvegicus1565658
4GPCR00545-HYDROXYTRYPTAMINE RECEPTOR_5-HT-1F_Rattus norvegicus8384716
5GPCR00935-HYDROXYTRYPTAMINE RECEPTOR_5-HT-5A_Rattus norvegicus7988681
6GPCR0175ADENOSINE RECEPTOR_A1_Rattus norvegicus1662665
7GPCR0236ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2A(Adrenoceptor)_Rattus norvegicus8662784
8GPCR0273ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2B(Adrenoceptor)_Rattus norvegicus2164221
9GPCR0299ADRENOCEPTOR (A2-ADRENOCEPTOR)_A2C(Adrenoceptor)_Rattus norvegicus2842764
10GPCR0190ADENOSINE RECEPTOR_A3_Rattus norvegicus-11323836
11GPCR0198ADENOSINE RECEPTOR_A3_Rattus norvegicus-21323836
12GPCR0442APJ RECEPTOR_Apelin_Rattus norvegicus9792798
13GPCR0411ANGIOTENSIN RECEPTOR_AT1_Rattus norvegicus-11310139
14GPCR0430ANGIOTENSIN RECEPTOR_AT1_Rattus norvegicus-21310139
15GPCR0439ANGIOTENSIN RECEPTOR_AT2_Rattus norvegicus8663053
16GPCR0399ADRENOCEPTOR (B-ADRENOCEPTOR)_B3(Adrenoceptor)_Rattus norvegicus9363896
17GPCR0994LEUKOTRIENE RECEPTOR_BLT_Rattus norvegicus9177352
18GPCR0702CHEMOTACTIC PEPTIDE RECEPTOR_C3A_Rattus norvegicus8702752
19GPCR0712CHEMOTACTIC PEPTIDE RECEPTOR_C5A_Rattus norvegicus7887933
20GPCR2639EXTRACELLULAR CALCIUM-SENSING RECEPTOR_CASR_Rattus norvegicus11152759
21GPCR0477CANNABINOID RECEPTOR_CB1_Rattus norvegicus-22165569
22GPCR0520CANNABINOID RECEPTOR_CB1_Rattus norvegicus-12165569
23GPCR0549CANNABINOID RECEPTOR_CB2_Rattus norvegicus7689702
24GPCR0562CHEMOKINE RECEPTOR (CC)_CCR2_Rattus norvegicus8530354
25GPCR0564CHEMOKINE RECEPTOR (CC)_CCR3_Rattus norvegicus8631813
26GPCR0579CHEMOKINE RECEPTOR (CC)_CCR5_Rattus norvegicus8639485
27GPCR0601CHEMOKINE RECEPTOR (CC)_CCR9_Rattus norvegicus10229797
28GPCR0607CHEMOKINE RECEPTOR (CX3C)_CX3CR1_Rattus norvegicus9390561
29GPCR0612CHEMOKINE RECEPTOR (CX3C)_CXCR1_Rattus norvegicus9390561
30GPCR0629CHEMOKINE RECEPTOR (CX3C)_CXCR2_Rattus norvegicus1891716
31GPCR0643CHEMOKINE RECEPTOR (CX3C)_CXCR4_Rattus norvegicus-28629022
32GPCR0664CHEMOKINE RECEPTOR (CX3C)_CXCR4_Rattus norvegicus-18629022
33GPCR0685CHEMOKINE RECEPTOR (CX3C)_CXCR4_Rattus norvegicus-38629022
34GPCR0692CHEMOKINE RECEPTOR (CX3C)_CXCR5_Rattus norvegicus11882900
35GPCR0788DOPAMINE RECEPTOR_D2_Rattus norvegicus2974511
36GPCR0796DOPAMINE RECEPTOR_D3_Rattus norvegicus1975644
37GPCR0800DOPAMINE RECEPTOR_D4_Rattus norvegicus1840645
38GPCR1884OPIOID AND OPIOID-LIKE RECEPTOR_DELTA OPIOID PEPTIDE (DOR)_Rattus norvegicus1335167
39GPCR2427PROSTANOID RECEPTOR_EP3_Rattus norvegicus11095474
40GPCR0824ENDOTHELIN RECEPTOR_ET-B_Rattus norvegicus1848367
41GPCR2730FRIZZLED_Frizzled-1_Rattus norvegicus11563835
42GPCR0843GLYCOPROTEIN HORMONE RECEPTOR_FSH RECEPTOR_Rattus norvegicus9139796
43GPCR2641GABA RECEPTOR_GABA-B-R1_Rattus norvegicus9872315
44GPCR2644GABA RECEPTOR_GABA-B-R2_Rattus norvegicus9872315
45GPCR0834GALANIN RECEPTOR_GAL1_Rattus norvegicus7524088
46GPCR0836GALANIN RECEPTOR_GAL2_Rattus norvegicus9685625
47GPCR0838GALANIN RECEPTOR_GAL3_Rattus norvegicus9722565
48GPCR0916GUSTATORY RECEPTOR_Gustatory receptor GUST27_Rattus norvegicus8670712
49GPCR0982HISTAMINE RECEPTOR_H3_Rattus norvegicus10347254
50GPCR0989HISTAMINE RECEPTOR_H4_Rattus norvegicus10973974
51GPCR1890OPIOID AND OPIOID-LIKE RECEPTOR_KAPPA OPIOID PEPTIDE (KOR)_Rattus norvegicus7624359
52GPCR1005LYSOPHOSPHOLIPID RECEPTOR_LPA1_Rattus norvegicus9070858
53GPCR1014LYSOPHOSPHOLIPID RECEPTOR_LPA3_Rattus norvegicus12069829
54GPCR0865GLYCOPROTEIN HORMONE RECEPTOR_LSH RECEPTOR_Rattus norvegicus1516719
55GPCR0125ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M2_Rattus norvegicus3443095
56GPCR0153ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M4_Rattus norvegicus3037705
57GPCR2797MELANIN-CONCENTRATING HORMONE RECEPTOR_MCHR1_Rattus norvegicus-210559938
58GPCR2651GLUTAMATE RECEPTOR (METABOTROPIC)_MGLU2_Rattus norvegicus1309649
59GPCR2655GLUTAMATE RECEPTOR (METABOTROPIC)_MGLU3_Rattus norvegicus1309649
60GPCR2656GLUTAMATE RECEPTOR (METABOTROPIC)_MGLU4_Rattus norvegicus1309649
61GPCR2661GLUTAMATE RECEPTOR (METABOTROPIC)_MGLU6_Rattus norvegicus8389366
62GPCR2663GLUTAMATE RECEPTOR (METABOTROPIC)_MGLU7_Rattus norvegicus8288585
63GPCR2664GLUTAMATE RECEPTOR (METABOTROPIC)_MGLU8_Rattus norvegicus9473604
64GPCR1221MELATONIN RECEPTOR_MT1_Rattus norvegicus7946354
65GPCR1232MELATONIN RECEPTOR_MT2_Rattus norvegicus12721330
66GPCR1907OPIOID AND OPIOID-LIKE RECEPTOR_MU OPIOID PEPTIDE (MOR)_Rattus norvegicus8393525
67GPCR1280NICOTINIC ACID RECEPTOR_NICOTINIC ACID_Rattus norvegicus15183629 | 12563315
68GPCR1913OPIOID AND OPIOID-LIKE RECEPTOR_N/OFQ RECEPTOR_Rattus norvegicus-115019559
69GPCR1916OPIOID AND OPIOID-LIKE RECEPTOR_N/OFQ RECEPTOR_Rattus norvegicus-215019559
70GPCR2554VASOPRESSIN AND OXYTOCIN RECEPTOR_OT_Rattus norvegicus1313946
71GPCR2385P2Y RECEPTOR_P2Y12_Rattus norvegicus11196645
72GPCR2455PROTEASE-ACTIVATED RECEPTOR_PAR1_Rattus norvegicus10644723
73GPCR2460PROTEASE-ACTIVATED RECEPTOR_PAR2_Rattus norvegicus15082510
74GPCR2464PROTEASE-ACTIVATED RECEPTOR_PAR3_Rattus norvegicus15082510
75GPCR2465PROTEASE-ACTIVATED RECEPTOR_PAR4_Rattus norvegicus15082510
76GPCR2411PLATELET ACTIVATING FACTOR (PAF) RECEPTOR_PLATELET ACTIVATING FACTOR (PAF) RECEPTOR_Rattus norvegicus7876256
77GPCR1043LYSOPHOSPHOLIPID RECEPTOR_S1P1_Rattus norvegicus-39488656
78GPCR1088LYSOPHOSPHOLIPID RECEPTOR_S1P2_Rattus norvegicus10488065
79GPCR1094LYSOPHOSPHOLIPID RECEPTOR_S1P3_Rattus norvegicus9409733
80GPCR1101LYSOPHOSPHOLIPID RECEPTOR_S1P5_Rattus norvegicus10799507
81GPCR1125LYSOPHOSPHOLIPID RECEPTOR_S1P-like_Rattus norvegicus-212220620
82GPCR1132LYSOPHOSPHOLIPID RECEPTOR_S1P-like_Rattus norvegicus-312220620
83GPCR1139LYSOPHOSPHOLIPID RECEPTOR_S1P-like_Rattus norvegicus-112220620
84GPCR2803SMOOTHENED_smoothened_Rattus norvegicus10835429
85GPCR2476SOMATOSTATIN RECEPTOR_SST1_Rattus norvegicus1346068
86GPCR2481SOMATOSTATIN RECEPTOR_SST2_Rattus norvegicus7622071
87GPCR2484SOMATOSTATIN RECEPTOR_SST3_Rattus norvegicus1337145
88GPCR2488SOMATOSTATIN RECEPTOR_SST4_Rattus norvegicus8483934
89GPCR2494SOMATOSTATIN RECEPTOR_SST5_Rattus norvegicus8373420
90GPCR0881GLYCOPROTEIN HORMONE RECEPTOR_TSH RECEPTOR_Rattus norvegicus8552586
91GPCR1246NEUROPEPTIDE Y RECEPTOR_Y1_Rattus norvegicus1321422
92GPCR1264NEUROPEPTIDE Y RECEPTOR_Y4_Rattus norvegicus7592911
93GPCR1266NEUROPEPTIDE Y RECEPTOR_Y5_Rattus norvegicus8700207



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