gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2558 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY VASOPRESSIN AND OXYTOCIN RECEPTOR
SUBFAMILY OT

Cross References:
UniProt P56449 EMBL AF101724
InterPro IPR000276 | IPR002062 | IPR001817 GPCRDB OXYR_BOVIN
GENEID 281371
PRINTS PR00237 | PR00665 | PR00896 PFAM PF00001

Details:
NAME VASOPRESSIN AND OXYTOCIN RECEPTOR_OT_Bos taurus
DESCRIPTION Oxytocin receptor (OT-R).
SPECIES Bos taurus COMMON NAME Bovine NCBI Taxonomy 9913
GENE OXTR
SEQUENCE 
MEGAFAANWSAEAVNGSAAPPGTEGNRTAGPPQRNEALARVEVAVLCLILFLALSGNACV
LLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQV
VGMFASTYLLLLMSLDRCLAICQPLRSLSRRTDRLAVLVTWLGCLVASAPQVHIFSLREV
ADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLATCYGLISFKIWQNLRLKTAAAAA
EAAAGAEGEAADWAGRAILARVSNVKLISKAKIRTVKMTFIVVLAFIVCWTPFFFVQMWS
VWDADAPKEASPFIIAMLLASLNSCCNPWIYMLFTGHLFQELVQRFLCCSFRRLKGSRPG
ETSVSKKSNSSTFVLSQYSSSQRRCSQPSTL
 FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12554793
HETERODIMER INFORMATION Forms functional heterodimers with V2 Receptors METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12554793
HETERODIMER INFORMATION Forms functional heterodimers with V1A Receptors METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12554793

Coupling with G-proteins:
Family:Gi/o REFERENCES:1313946
1GPR0017Galpha-o1-Bos taurus
2GPR0219Galpha-i1-Bos taurus
3GPR0294Galpha-i2-Bos taurus-2
4GPR0295Galpha-i2-Bos taurus-1
Family:Gq/11 REFERENCES:1313946
5GPR0027Galpha-11-Bos taurus

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athina University of Athens
 Faculty of Biology
 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory