gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2663 ::
CLASS CLASS C (METABOTROPIC GLUTAMATE / PHEROMONE)
FAMILY GLUTAMATE RECEPTOR (METABOTROPIC)
SUBFAMILY MGLU7

Cross References:
UniProt P35400 EMBL D16817 | U06832
InterPro IPR001828 | IPR000337 | IPR000162 | IPR001883 | IPR011500 PDB 2E4Z GPCRDB GRM7_RAT
GENEID 81672
PRINTS PR00248 | PR01057 | PR00593 PFAM PF00003 | PF01094 | PF07562

Details:
NAME GLUTAMATE RECEPTOR (METABOTROPIC)_MGLU7_Rattus norvegicus
DESCRIPTION Metabotropic glutamate receptor 7 precursor (mGluR7).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Grm7 | Gprc1g | Mglur7
SEQUENCE 
MVQLGKLLRVLTLMKFPCCVLEVLLCVLAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAK
GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL
TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA
STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ
ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK
RADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR
NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAH
ALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRHVNFNGSAGTPVMFNKNGDAPGRYDIF
QYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPSSVCTLPCKPGQRKKTQKGTP
CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQNIPIIKLEWHSPWAVIPVFLAML
GIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRV
FLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW
FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGV
PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML
YMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS
PAAKKKYVSYNNLVI
 FRAGMENT NO

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Scaffold:
TYPE alpha-filamin/ABP280( actin binding protein 280) REFERENCES 12570872
TYPE GRIP1( glutamate receptor interacting protein 1) REFERENCES 11891216
TYPE GRIP1( glutamate receptor interacting protein 1) REFERENCES 11891216
TYPE PICK1( protein interacting with protein kinase) REFERENCES 11891216
TYPE Syntenin REFERENCES 12570872 | 1189121

Coupling with G-proteins:
Family:Gi/o REFERENCES:8288585
1GPR0026Galpha-o-Rattus norvegicus
2GPR0111Galpha-i3-Rattus norvegicus
3GPR0221Galpha-i1-Rattus norvegicus
4GPR0229Galpha-i2-Rattus norvegicus

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athina University of Athens
 Faculty of Biology
 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory