| Details: |
| NAME |
ANGIOTENSIN RECEPTOR_AT1_Cavia porcellus-1 |
| DESCRIPTION |
Type-1 angiotensin II receptor (AT1). |
| SPECIES |
Cavia porcellus |
COMMON NAME |
Guinea pig |
NCBI Taxonomy |
10141 |
| GENE |
AGTR1 |
| SEQUENCE |
MILNSSTEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADICFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCVIIWLMAGLASLPAVIHRNVFFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFMFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFK
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIHDCKISDIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSTLSTKMSTLSYRPSDNVSSSAKKPVQCFEVE
|
FRAGMENT |
NO
|
|
|
|
|
Homepage
|
| Dimerization: |
| HOMODIMER INFORMATION |
There is experimental evidence for homo-dimerization
|
METHOD |
functional complementation
|
REFERENCES |
8576145
|
| HETERODIMER INFORMATION |
Forms heterodimer with AT2 Receptor. After the dimerization the AT2 receptor antagonizes function of the AT1 receptor
|
METHOD |
Immunoprecipitation
|
REFERENCES |
11507095
|
| HETERODIMER INFORMATION |
Forms heterodimer with Bradykinin B2 Receptor. Dimerization results in increased signalling activity
|
METHOD |
Immunoprecipitation
|
REFERENCES |
10993080
|
| Scaffold: |
| TYPE |
eNOS( endothelial nitric oxide synthase) /cNOS/NOS3
|
REFERENCES |
12842859
|
| TYPE |
JAK2( Janus kinase)
|
REFERENCES |
9287353
|
| Coupling with G-proteins: |
| Family:Gi/o |
REFERENCES: | 1310139 | | 1 | GPR0107 | Galpha-i3-Cavia porcellus | | 2 | GPR0216 | Galpha-i1-Cavia porcellus | | 3 | GPR0224 | Galpha-i2-Cavia porcellus |
|
biol.uoa.gr
for comments, corrections and
data (sequence) submission.
