gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0415 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ANGIOTENSIN RECEPTOR
SUBFAMILY AT1

Cross References:
UniProt P35373 EMBL U01155
InterPro IPR000190 | IPR000248 | IPR001186 | IPR000276 GPCRDB AGTRM_XENLA
GENEID 378523
PRINTS PR00241 | PR00635 | PR00993 | PR00237 PFAM PF00001

Details:
NAME ANGIOTENSIN RECEPTOR_AT1_Xenopus laevis-2
DESCRIPTION Type-1-like angiotensin II receptor 2 (AT1).
SPECIES Xenopus laevis COMMON NAME African clawed frog NCBI Taxonomy 8355
GENE -
SEQUENCE
MLSNISAGENSEVEKIVVKCSKSGMHNYIFITIPIIYSTIFVVGVFGNSLVVIVIYSYMK
MKTMASVFLMNLALSDLCFVITLPLWAVYTAMHYHWPFGDLLCKIASTAITLNLYTTVFL
LTCLSIDRYSAIVHPMKSRIRRTVMVARLTCVGIWLVAFLASLPSVIYRQIFIFPDTNQT
VCALVYHSGHIYFMVGMSLVKNIVGFFIPFVIILTSYTLIGKTLKEVYRAQRARNDDIFK
MIVAVVLLFFFCWIPHQVFTFLDVLIQMDVIQNCKMYDIVDTGMPITICIAYFNSCLNPF
LYGFFGKKFRKHFLQLIKYIPPKMRTHASVNTKSSTVSQRLSDTKCASNKIALWIFDIEE
HCK
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD functional complementation REFERENCES 8576145
HETERODIMER INFORMATION Forms heterodimer with AT2 Receptor. After the dimerization the AT2 receptor antagonizes function of the AT1 receptor METHOD Immunoprecipitation REFERENCES 11507095
HETERODIMER INFORMATION Forms heterodimer with Bradykinin B2 Receptor. Dimerization results in increased signalling activity METHOD Immunoprecipitation REFERENCES 10993080

Scaffold:
TYPE eNOS( endothelial nitric oxide synthase) /cNOS/NOS3 REFERENCES 12842859
TYPE JAK2( Janus kinase) REFERENCES 9287353

Coupling with G-proteins:
Family:Gi/o REFERENCES:1310139
1GPR0016Galpha-o-Xenopus laevis
2GPR0112Galpha-i3-Xenopus laevis
3GPR0222Galpha-i1-Xenopus laevis
4GPR0271Galpha-o1-Xenopus laevis
5GPR0272Galpha-i-Xenopus laevis
Family:Gq/11 REFERENCES:8865167
6GPR0033Galpha-11-Xenopus laevis-2
7GPR0243Galpha-q-Xenopus laevis
8GPR0314Galpha-11-Xenopus laevis-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory