gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0467 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY BRADYKININ RECEPTOR
SUBFAMILY B2

Cross References:
UniProt P30411 EMBL M88714 | S56772 | X69680 | S45489 | L27594 | X86165 | X86164 | AY275465 | AF378542 | BC074894 | BC074895
InterPro IPR001504 | IPR000496 | IPR000276 GPCRDB BKRB2_HUMAN
GENEID 624 MIM 113503
PRINTS PR00425 | PR00994 | PR00237 PFAM PF00001

Details:
NAME BRADYKININ RECEPTOR_B2_Homo sapiens
DESCRIPTION B2 bradykinin receptor (BK-2 receptor) (B2R).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE BDKRB2 | BKR2
SEQUENCE
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQ
PPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNN
FDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLV
IWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVI
TFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGI
LSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEP
IQMENSMGTLRTSISVERQIHKLQDWAGSRQ
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Cross-linking in the presence of agonist REFERENCES 10473556
HETERODIMER INFORMATION Forms heterodimer with Angiotensin AT1 Receptor. Dimerization results in increased signalling activity METHOD Immunoprecipitation REFERENCES 10993080

Scaffold:
TYPE eNOS( endothelial nitric oxide synthase) /cNOS/NOS3 REFERENCES 10681501
TYPE nNOS( neuronal nitric oxide synthase) NOS1 REFERENCES 10681501

Coupling with G-proteins:
Family:G12/13 REFERENCES:7946358
1GPR0034Galpha-12-Homo sapiens
2GPR0037Galpha-13-Homo sapiens
Family:Gq/11 REFERENCES:1657928
3GPR0002Galpha-q-Homo sapiens-2
4GPR0029Galpha-11-Homo sapiens
5GPR0237Galpha-q-Homo sapiens-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory