gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0472 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY BRADYKININ RECEPTOR
SUBFAMILY B2

Cross References:
UniProt Q9BDQ4 EMBL AF334948
InterPro IPR001504 | IPR000496 | IPR000276 GPCRDB Q9BDQ4_CANFA
GENEID 403658
PRINTS PR00425 | PR00994 | PR00237 PFAM PF00001

Details:
NAME BRADYKININ RECEPTOR_B2_Canis familiaris
DESCRIPTION B2 bradykinin receptor.
SPECIES Canis familiaris COMMON NAME Dog NCBI Taxonomy 9615
GENE Bdkrb2
SEQUENCE
MFSAWKRPMFLSFHEDPVPTTASLSTEMFNSTSQDLMPTLNGTLPSPCVYPEWWNWLNTI
QAPFLWVLFILAALENLFVLSIFCLHKSSCTVAEIYLGNLALADLILASGLPFWAITIAN
NFDWLFGEVLCRVVNTMLYMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSL
VIWGCTLLLSSPMLAFRTMKEYRDEGYNVTACVIIYPSRTWEVFTNVLLNFVGFLLPLTV
ITFCTVQIMQVLRNNEMQKFKEIQTERKATVLVLAVLLLFVICWLPFQISTFLDTLLRLD
ILSGCRHEHLVDVFTQIASYVAYSNSCLNPLVYVIVGKRFRKKSREVFRGLCQKGGCVLE
SNKMDNSMGTLRTSVSVERQIHKLPEWAENSQ
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Cross-linking in the presence of agonist REFERENCES 10473556
HETERODIMER INFORMATION Forms heterodimer with Angiotensin AT1 Receptor. Dimerization results in increased signalling activity METHOD Immunoprecipitation REFERENCES 10993080

Scaffold:
TYPE eNOS( endothelial nitric oxide synthase) /cNOS/NOS3 REFERENCES 10681501
TYPE nNOS( neuronal nitric oxide synthase) NOS1 REFERENCES 10681501

Coupling with G-proteins:
Family:Gq/11 REFERENCES:1657928
1GPR0233Galpha-q-Canis familiaris


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory