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gpDB::GPCR View
Entry 1 of 1 :: GPCR0629 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY CHEMOKINE RECEPTOR (CX3C)
SUBFAMILY CXCR2

Cross References:
UniProt P35407 EMBL X77797 | D63584 | U70988
InterPro IPR001277 | IPR000276 | IPR000174 | IPR000057 GPCRDB CXCR2_RAT
GENEID 29385
PRINTS PR00645 | PR00237 | PR00427 | PR00573 PFAM PF00001

Details:
NAME CHEMOKINE RECEPTOR (CX3C)_CXCR2_Rattus norvegicus
DESCRIPTION High affinity interleukin-8 receptor B (IL-8R B) (CXCR-2) (GRO/MGSAreceptor) (CD182 antigen).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Il8rb | Cxcr2
SEQUENCE
MGEIRVDNFSLEDFFSGDIDSYNYSSDPPFTLSDAAPCPSANLDINRYAVVVIYVLVTLL
SLVGNSLVMLVILYNRSTCSVTDVYLLNLAIADLFFALTLPVWAASKVNGWIFGSFLCKV
FSFLQEITFYSSVLLLACISMDRYLAIVHATSTLIQKRHLVKFVCITMWFLSLVLSLPIF
ILRTTVKANPSTVVCYENIGNNTSKWRVVLRILPQTYGFLLPLLIMLFCYGFTLRTLFKA
HMGQKHRAMRVIFAVVLVFLLCWLPYNIVLFTDTLMRTKLIKETCERQNEINKALEATEI
LGFLHSCLNPIIYAFIGQKFRHGLLKIMANYGLVSKEFLAKEGRPSFVGSSSANTSTTL
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 12888558

Scaffold:
TYPE beta-arrestin-1 - 2 REFERENCES 10973280

Coupling with G-proteins:
Family:Gi/o REFERENCES:1891716
1GPR0026Galpha-o-Rattus norvegicus
2GPR0111Galpha-i3-Rattus norvegicus
3GPR0221Galpha-i1-Rattus norvegicus
4GPR0229Galpha-i2-Rattus norvegicus


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
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Laboratory