gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0754 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY DOPAMINE RECEPTOR
SUBFAMILY D1

Cross References:
UniProt P42289 EMBL U07863
InterPro IPR015694 | IPR001413 | IPR000929 | IPR000276 GPCRDB DRD1_XENLA
PRINTS PR00565 | PR00242 | PR00237 PFAM PF00001

Details:
NAME DOPAMINE RECEPTOR_D1_Xenopus laevis-2
DESCRIPTION D(1A) dopamine receptor.
SPECIES Xenopus laevis COMMON NAME African clawed frog NCBI Taxonomy 8355
GENE drd1
SEQUENCE
MTFNITSMDEDVLLTERESSFRVLTGCFLSVLILSTLLGNTLVCAAVIRFRHLRSKVTNF
FVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGTFCNIWVAFDIMCSTASILNLCVISVDR
YWAISSPFRYERKMTPKVAFIMIGVAWTLSVLISFIPVQLNWHKAKTTSFFDLNITLHDR
TMDNCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAAKQIRRISALERAAVHAKNC
QNSTSNRNSLDCQQPESSLKTSFKRETKVLKTLSVIMGVFVCCWLPFFILNCIVPFCDPS
LTTSGTEPFCISSTTFDVFVWFGWANSSLNPIIYAFNADFRKAFSNLLGCYRLCPTSNNI
IETVSINNNGAVVYSCQQEPKGSIPNECNLVYLIPHAIICPEDEVLKKEDESGLSKSLEK
MSPAFSGILDYDADVSLEKINPITQNGQPKT
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 9804783
HETERODIMER INFORMATION Forms heterodimers with Adenosine A1 Receptor. Heterodimerization results in altered D1 receptor signalling METHOD Immunoprecipitation REFERENCES 10890919

Coupling with G-proteins:
Family:Gs REFERENCES:2144334
1GPR0127Galpha-s-Xenopus laevis


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