gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0977 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY HISTAMINE RECEPTOR
SUBFAMILY H2

Cross References:
UniProt P25021 | Q14464 EMBL M64799 | D49783 | AB023486 | AB041384 | AY136744 | X98133
InterPro IPR000276 | IPR000503 GPCRDB HRH2_HUMAN
GENEID 3274 MIM 142703
PRINTS PR00237 | PR00531 PFAM PF00001

Details:
NAME HISTAMINE RECEPTOR_H2_Homo sapiens
DESCRIPTION Histamine H2 receptor (H2R) (Gastric receptor I).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE HRH2
SEQUENCE 
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
 FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 9202162

Coupling with G-proteins:
Family:Gs REFERENCES:1703298
1GPR0119Galpha-s-Homo sapiens-2
2GPR0263Galpha-s-Homo sapiens-4
3GPR0266Galpha-s-Homo sapiens-5
4GPR0267Galpha-s-Homo sapiens-6
5GPR0277Galpha-s-Homo sapiens-7
6GPR0278Galpha-s-Homo sapiens
7GPR0395Galpha-s-Homo sapiens-3

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athina University of Athens
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