Photo Paraskevi Tsiolaki

PhD Student
etsiolakibiol.uoa.gr

EDUCATION
2014 - present: PhD in Structural Biology (Biophysics), Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens
Thesis: “Studies of structure and self-assembly of amyloidogenic proteins and amyloidogenic peptide-analogues, implicated with amyloidoses and functional amyloid formation” under the guidance of Assistant Professor Vasiliki A. Iconomidou, Professor Stavros J. Hamodrakas, Professor Konstantinos E. Vorgias

2012 - 2014: MSc in Bioinformatics, Faculty of Biology, University of Athens
Thesis: “Correlation between sequence and structure of amyloidogenic proteins” under the guidance of Professor Stavros J. Hamodrakas and Lecturer Vassiliki A. Iconomidou, Department, of Cell Biology & Biophysics, Faculty of Biology, National & Kapodistrian University of Athens

2005 - 2012: BSc in Biology, Faculty of Biology, University of Athens
Thesis: “Cystatin C as a model/protein in amyloid formation mechanisms and amyloidoses” under the guidance of Professor Stavros J. Hamodrakas and Lecturer Vassiliki A. Iconomidou Department of Cell Biology & Biophysics, Faculty of Biology, National & Kapodistrian University of Athens


RESEARCH INTERESTS
My research interests are focused on Structural biology/Molecular Biophysics. Specifically I am interested in structural studies of amyloidogenic proteins and peptide-analogues, either associated with conformational diseases, such as amyloidosis, or involved in the formation of functional amyloids. Moreover, I am currently working on computational and structural analysis of protein aggregation as an anomalous type of protein-protein interactions.

PUBLICATIONS Search in
Biza, K.V.*, Nastou, K.C.*, Tsiolaki, P.L.*, Mastrokalou, C.V., Hamodrakas, S.J., Iconomidou, V.A. (2017) The amyloid interactome: Exploring protein aggregation. PLoS ONE Mar 1;12(3):e0173163. [Abstract] [PDF] (*: Equally contributing authors) doi:10.1371/journal.pone.0173163.
Tsiolaki, P.L., Louros, N.N., Zompra, A.A.,Hamodrakas, S.J., Iconomidou, V.A. (2016) Unraveling the aggregation propensity of human insulin C-peptide. Biopolymers. 2016 Jun 3. [Epub ahead of print] [Abstract] [PDF] doi: 10.1002/bip.22882.
Louros, N.N., Bolas, G.M., Tsiolaki, P.L., Hamodrakas, S.J., Iconomidou, V.A. (2016) Intrinsic Aggregation Propensity of the CsgB Nucleator Protein is Crucial for Curli Fiber Formation. J. Struct. Biol. Aug;195(2):179-89. Epub 2016 May 28. [Abstract] [PDF] doi: 10.1016/j.jsb.2016.05.012.
Tsiolaki, P.L., Louros, N.N., Hamodrakas, S.J., Iconomidou, V.A. (2015) Exploring the 'aggregation-prone' core of human Cystatin C: A structural study. J. Struct. Biol. Sep;191(3):272-80. Epub 2015 Jul 31. [Abstract] [PDF] doi: 10.1016/j.jsb.2015.07.013
Louros, N.N., Tsiolaki, P.L., Griffin, M.D., Howlett, G.J., Hamodrakas, S.J., Iconomidou, V.A. (2015) Chameleon 'aggregation-prone' segments of apoA-I: A model of amyloid fibrils formed in apoA-I amyloidosis. Int. J. Biol. Macromol. Volume 79, pp. 711-718, August 2015. [Abstract] [PDF] doi: 10.1016/j.ijbiomac.2015.05.032
Louros, N.N., Tsiolaki, P.L., Zompra, A.A., Pappa, E.V., Magafa, V., Pairas, G., Cordopatis, P., Cheimonidou, C., Trougakos, I.P., Iconomidou, V.A., Hamodrakas, S.J.(2015) Structural Studies and Cytotoxicity Assays of "Aggregation-Prone" IAPP8-16 and its Non-Amyloidogenic Variants Suggest its Important Role in Fibrillogenesis and Cytotoxicity of Human Amylin (hIAPP). Biopolymers Volume 104, Issue 3, pp. 196-205, May 2015.[Abstract] [PDF] doi: 10.1002/bip.22650
Tsiolaki, P.L., Hamodrakas, S.J., Iconomidou, V.A. (2015) The pentapeptide LQVVR plays a pivotal role in human cystatin C fibrillization. 2015 Jan 2;589(1):159-64. Epub 2014 Dec 3. [Abstract] [PDF]
Louros, N.N., Iconomidou, V.A., Tsiolaki, P.L., Chrysina, E.D., Baltatzis, G.E., Patsouris, E.S., Hamodrakas, S.J. (2014) An N-terminal pro-atrial natriuretic peptide (NT-proANP) 'aggregation-prone' segment involved in isolated atrial amyloidosis. FEBS Lett., 588: 52-57. [Abstract] [PDF]