gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::Effector View
Entry 1 of 1 :: EFF0868 ::
FAMILY Tyr protein kinases
SUBFAMILY Tyr protein kinases
TYPE Src tyrosine kinase

Cross References:
UniProt P32577 | Q4G003 EMBL X58631 | BC098863
InterPro IPR015778 | IPR000719 | IPR000980 | IPR001452 | IPR001245 | IPR008266 PDB 1K9A
PRODOM PD000001 | PD000093 | PD000066 GENEID 315707
PRINTS PR00401 | PR00452 | PR00109 PFAM PF07714 | PF00017 | PF00018

Details:
NAME Src tyrosine kinase-Rattus norvegicus-2
DESCRIPTION Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Csk
SEQUENCE 
MSAIQASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
SCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQ
DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
TQLRHSNLVQLLGVI
 FRAGMENT NO
FUNCTION Specifically phosphorylates 'Tyr-504' on LCK, which actss as a negative regulatory site
Interacting with G-proteins:
Family:Gi/o REFERENCES:11007482 | 15251227 | 12209124
1GPR0111Galpha-i3-Rattus norvegicus
2GPR0221Galpha-i1-Rattus norvegicus
3GPR0229Galpha-i2-Rattus norvegicus
4GPR0026Galpha-o-Rattus norvegicus
Family:Gs REFERENCES:11007482 | 15251227 | 12209124
5GPR0124Galpha-s-Rattus norvegicus-2
6GPR0392Galpha-s-Rattus norvegicus-1

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