gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR1246 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY NEUROPEPTIDE Y RECEPTOR
SUBFAMILY Y1

Cross References:
UniProt P21555 EMBL Z11504
InterPro IPR000276 | IPR000351 | IPR000611 GPCRDB NPY1R_RAT
PRINTS PR00237 | PR01013 | PR01012 PFAM PF00001

Details:
NAME NEUROPEPTIDE Y RECEPTOR_Y1_Rattus norvegicus
DESCRIPTION Neuropeptide Y receptor type 1 (NPY1-R) (FC5).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Npy1r
SEQUENCE
MNSTLFSRVENYSVHYNVSENSPFLAFENDDCHLPLAVIFTLALAYGAVIILGVSGNLAL
IIIILKQKEMRNVTNILIVNLSFSDLLVAVMCLPFTFVYTLMDHWVFGETMCKLNPFVQC
VSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYIGITVIWVLAVASSLPFVIYQILTD
EPFQNVSLAAFKDKYVCFDKFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRR
NNMMDKIRDSKYRSSETKRINVMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLL
FLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSK
TSLKQASPVAFKKISMNDNEKI
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Fluorescence Resonance Energy Transfer (FRET) REFERENCES 12524448

Coupling with G-proteins:
Family:Gi/o REFERENCES:1321422
1GPR0026Galpha-o-Rattus norvegicus
2GPR0111Galpha-i3-Rattus norvegicus
3GPR0221Galpha-i1-Rattus norvegicus
4GPR0229Galpha-i2-Rattus norvegicus
Family:Gq/11 REFERENCES:1321422
5GPR0032Galpha-11-Rattus norvegicus
6GPR0242Galpha-q-Rattus norvegicus


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