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gpDB::GPCR View
Entry 1 of 1 :: GPCR0136 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ACETYLCHOLINE RECEPTOR (MUSCARINIC)
SUBFAMILY M3

Cross References:
UniProt Q9ERZ3 | Q64055 EMBL AF264050 | S74908
InterPro IPR000276 | IPR001183 | IPR000995 GPCRDB ACM3_MOUSE
GENEID 12671
PRINTS PR00237 | PR00243 | PR00540 PFAM PF00001

Details:
NAME ACETYLCHOLINE RECEPTOR (MUSCARINIC)_M3_Mus musculus
DESCRIPTION Muscarinic acetylcholine receptor M3 (Mm3 mAChR).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Chrm3 | Chrm-3
SEQUENCE
MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVSQLDSYNISQTSGNFSSNDTSSDPLG
GHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVIS
MNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRT
TKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFY
MPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGTK
RSSRRKYGGCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSET
RAIYSIVLKLPGHSTILNSTKLPSSDNLQVPDKDLGTMDVERNAHKLQAQKSMDDRDNCQ
KDFSKLPIQLESAVDTAKTSDTNSSVDKTTAALPLSFKEATLAKRFALKTRSQITKRKRM
SLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNP
VCYALCNKTFRTTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10383466
HETERODIMER INFORMATION Forms heterodimers with Muscarinic M2 Receptors. Heterodimerization results in altered internalization of the receptors METHOD Chimeric receptor reconstitution studies REFERENCES 10490911

Coupling with G-proteins:
Family:G12/13 REFERENCES:11036069
1GPR0035Galpha-12-Mus musculus
2GPR0038Galpha-13-Mus musculus-2
3GPR0323Galpha-13-Mus musculus-3
4GPR0380Galpha-13-Mus musculus-1
Family:Gq/11 REFERENCES:11242080
5GPR0031Galpha-11-Mus musculus-2
6GPR0240Galpha-q-Mus musculus
7GPR0360Galpha-11-Mus musculus-1


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory