gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR2455 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY PROTEASE-ACTIVATED RECEPTOR
SUBFAMILY PAR1

Cross References:
UniProt P26824 EMBL M81642
InterPro IPR000276 | IPR003912 | IPR000935 GPCRDB PAR1_RAT
PRINTS PR00237 | PR01428 | PR00908 PFAM PF00001

Details:
NAME PROTEASE-ACTIVATED RECEPTOR_PAR1_Rattus norvegicus
DESCRIPTION Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE F2r | Par1
SEQUENCE
MGPRRLLLVAVGLSLCGPLLSSRVPMRQPESERMYATPYATPNPRSFFLRNPSEDTFEQF
PLGDEEEKNESIPLEGRAVYLNKSRFPPMPPPPFISEDASGYLTSPWLTLFIPSVYTFVF
IVSLPLNILAIAVFVFRMKVKKPAVVYMLHLAMADVLFVSVLPFKISYYFSGTDWQFGSG
MCRFATAACYCNMYASIMLMTVISIDRFLAVVYPIQSLSWRTLGRANFTCVVIWVMAIMG
VVPLLLKEQTTQVPGLNITTCHDVLNETLLHGFYSYYFSAFSAIFFLVPLIISTVCYTSI
IRCLSSSAVANRSKKSRALFLSAAVFCIFIVCFGPTNVLLIVHYLLLSDSPGTETAYFAY
LLCVCVTSVASCIDPLIYYYASSECQKHLYSILCCRESSDSNSCNSTGQLMPSKMDTCSS
HLNNSIYKKLLA
FRAGMENT NO

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Scaffold:
TYPE SNX1( sorting nexin) REFERENCES 12058063

Coupling with G-proteins:
Family:G12/13 REFERENCES:12954641
1GPR0036Galpha-12-Rattus norvegicus
Family:Gi/o REFERENCES:10644723
2GPR0026Galpha-o-Rattus norvegicus
3GPR0111Galpha-i3-Rattus norvegicus
4GPR0221Galpha-i1-Rattus norvegicus
5GPR0229Galpha-i2-Rattus norvegicus
Family:Gq/11 REFERENCES:10644723
6GPR0032Galpha-11-Rattus norvegicus
7GPR0242Galpha-q-Rattus norvegicus


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
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Laboratory